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Alzheimer’s disease is marked by the abnormal accumulation of two proteins: plaques made of Beta-Amyloid (ABeta) and neurofibrillary tangles of phosphorylated Tau (P-Tau). This is a 3D image was taken of a section of tissue from a 14 month old mouse expressing the protein that leads to ABeta plaques. Green is a stain for microglia, immune cells of the brain which are migrating toward an ABeta plaque. Red is a stain for P-Tau, which has accumulated at the site of the plaque. Blue marks cell nuclei.